A Vertically‐Stacked Optoelectronic Sensor for Localized Hemodynamics Monitoring

Abstract

<jats:title>Abstract</jats:title><jats:p>Optoelectronic sensors are widely used as they monitor important biosignals in real‐time, many times in non‐invasive ways by making use of the degree of light absorption through live tissues. In many of the applications, the optoelectronic sensors in a small form factor with attachable or insertable forms enable understanding the critically important biological states and mechanisms, including localized activities in very complex biological environments, such as in the brain. In this report, an optoelectronic sensor is presented, built by vertically integrating two different micro light emitting diodes (microLEDs) next to a photodetector with a predetermined interoptode distance in attachable or insertable forms. Both of the optical simulations and experimental results validate the designs and capabilities of the approach, by demonstrating the sensors on a human finger, around femoral vessels in a mouse model, and in mouse brains to monitor optogenetically‐induced localized hemodynamics.</jats:p>