GIST Scholar
College of Life Sciences and Medical Engineering
Department of Biomedical Science and Engineering
1. Journal Articles
Tau beyond the Brain: Endoplasmic Reticulum Stress and Tau Phosphorylation as Emerging Drivers of Diabetic Nephropathy
- Type
- Article
- Citation
- Diabetes and Metabolism Journal, v.50, no.5, pp.884 - 886
- Issued Date
- 2026-09
- Abstract
- Diabetic nephropathy (DN) is the leading cause of end-stage kidney disease worldwide, affecting approximately 40% of all individuals with diabetes mellitus and contributing to a nearly 38% increase in age-standardized mortality rate over the past three decades [1]. Despite notable advances in treatment methods based on renin-angiotensin system blockade and sodiumglucose cotransporter 2 inhibition, a substantial proportion of patients progress to kidney failure, underscoring the need for a deeper understanding of the pathogenic mechanisms that drive glomerular injury and tubular damage. Investigation into potential mediators of renal injury has recently focused on tau, a microtubule-associated protein canonically associated with neurodegenerative tauopathies such as Alzheimer’s disease (AD). In this issue of the Diabetes & Metabolism Journal, Lee et al. [2] provide mechanistic evidence that site-specific tau phosphorylation and endoplasmic reticulum (ER) stress contribute to DN pathogenesis, expanding the scope of therapeutic opportunities.
- Publisher
- 대한당뇨병학회
- ISSN
- 2233-6079
- Appears in Collections:
- Department of Biomedical Science and Engineering > 1. Journal Articles
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