Physiological role of miRNAs in CD4+ T cell-derived T cell microvilli particle for Dendritic cell activation

Abstract

Microvilli on T cells have an important role in the process of recognition and interaction with antigen-presenting cells (APC). T cells contact with APC through extension of microvilli and release microvilli as large T cell microvilli particles (TMPs) in a process of trogocytosis on the surface of cognate APC. Especially TMPs from CD4+ T cell contain various bioactive molecules and activate dendritic cells. Here, we demonstrate that CD4+ T cell-derived T cell microvilli particles (TMPs) are enriched with numerous microRNAs and transferred to dendritic cells. Transfected miRNAs target and regulate the expression of specific target genes in dendritic cells. In addition, TMPs from CD4+ T cells induce dendritic cells to be activated. In this study, we suggest the connection of miRNAs in TMP and dendritic cell activation.