미세유체 채널에서 적혈구 배향에 대한 실험적 및 이론적 연구

Abstract

Electrochemical impedance spectroscopy of whole blood has great potential for assessing the health of patients. In this study, electrochemical impedance spectra of whole blood were measured in microfluidic channel. The high volume fraction and high shear rate cause the orientation of erythrocytes in the flow. This study mainly focuses on this effect. The measuring system consists of a microfluidic channel with electrodes located on the walls perpendicular and parallel to the flow, and an impedance analyzer. The impedance spectra of blood were measured at frequencies from 1 kHz to 110 MHz. The effective medium theory was used to analyze the experimental data. The preferred orientation factor was introduced to characterized erythrocyte motion. It was shown that about 0.66 erythrocytes have a random distribution, and about 0.34 of them occupy a random position and have the same orientation along the channel for a wide range of blood flow rates.