GC-APCI- and LC-ESI-MS for a comprehensive analysis of household chemical products

Abstract

Human health risk that could be originated from undisclosed ingredients in household chemical products (HCPs) has raised the importance of toxicological analysis of unknown compounds in HCPs. A wide range of physicochemical properties of HCPs necessitate the use of different analytical techeniques to cover them. Herein, we analyzed 14 HCPs using GC-APCI- and LC-QTOF-MS/MS for a comprehensive analysis of their ingredients. Untargeted LC-MS/MS analysis of 5 HCPs identified an unreported potential toxicant, erucamide, which was confirmed with a pure standard commercially available. Untargeted GC-APCI-MS/MS analysis of HCPs also tentatively identified other 11 potential toxicants. These results demonstrated the utility of using both GC-APCI- and LC-ESI-MS/MS for comprehensive identification of potential toxicants in non-target analysis of HCPs.