The effects of serotonin by Tph1 and Htr2b on skeletal muscle

Abstract

-fat diet, and the role of serotonin in skeletal muscle. The findings suggest that central serotonin in the human brain regulates fatty acid metabolism, mitochondrial biogenesis, and quality control. TPH1 expressions in the small intestine and colon have significant associations with hormone and nutrition regulation. Additionally, inhibiting Tph1 and Htr2b increases AMPK activity, glucose uptake, and myofiber size and decreases lipid droplet accumulation in HFD mice’s skeletal muscle. These results indicate improved insulin resistance and myosteatosis in skeletal muscle by lack of serotonin by Tph1 and Htr2b on skeletal muscle. These results provide strong evidence that serotonin plays significant roles in critical pathways such as mitochondrial homeostasis, energy metabolism, and organ development.