New therapy for colorectal cancer targeting cancer metabolism through serotonin receptor HTR2B

Abstract

Serotonin is important material in our body. 5-HT is synthesized by TPH1 starting with tryptophan and this compound exists on colorectal cancer tumor. And serotonin combines with various receptors to conduct the metabolic pathway in colorectal cancer. Each receptor relates with various metabolism, such as lipid metabolism, growth, immunity, etc. In this way, medicine which inhibits these receptors can expect for therapy of colorectal cancer. Especially, HTR 2B has correlation with growth factor and using the inhibitor of HTR2B, SB204741, can have effect on metabolic pathway in colorectal cancer. To determine the way that SB204741 can effect on proliferation of colorectal cancer, we conduct the various experiments. We identified the decrease tendency of growth rate in colorectal cancer cell. And we created the colorectal cancer tumor using Colo 205 in mouse. The tumor size decreased and we demonstrated that the proliferation of tumor decreased using immunofluorescence. Moreover, we find the new compound that has similar effect with SB204741 by conducting the same experiments. We can expect that this new compound can be a candidate for therapy of colorectal cancer.