GIST Repository
College of Life Sciences and Medical Engineering
Department of Biomedical Science and Engineering
4. Theses(Ph.D)
Neurobiological Impact of Transcranial Photobiomodulation on the Sleep-wake Regulation in Mice
- Abstract
- Neurobiological Impact of Transcranial Photobiomodulation on the Sleep-wake Regulation in Mice
- Issued Date
- 2024
- Type
- Thesis
- Alternative Author(s)
- 정지은
- Department
- 대학원 의생명공학과
- Advisor
- Kim, Tae
- Table Of Contents
- Disturbed sleep patterns present a critical health issue in contemporary society, often addressed through pharmacological and cognitive behavioral interventions, which may exhibit restricted efficacy and adverse effects. The neuromodulator adenosine, known for its sleep-inducing properties, presents an opportunity for novel sleep therapies, yet efficacious methods to amplify intracranial adenosine for sleep enhancement remain underexplored. Photobiomodulation (PBM) with near-infrared light may be a potential solution, as it promotes mitochondrial ATP synthesis, subsequently leading to the extracellular release and metabolic conversion to adenosine. This research investigates the prospect of transcranial PBM (tPBM) as a therapeutic intervention to enhance sleep quality. I implanted electroencephalography electrodes and secured a fiber optic cannula into the skulls of mice to monitor and influence brain activity in response to the tPBM. I then administered tPBM using a continuous-wave broadband light source with an 810 nm optical bandpass filter. The treatment was applied for three hours, either at the start of the light phase or the end of the dark phase. Compared to a sham stimulation control, I observed increased non-rapid eye movement (NREM) sleep during and after tPBM. tPBM led to more frequent but shorter episodes of wakefulness and NREM sleep during treatment, which normalized post-tPBM. Additionally, NREM delta power was higher during and after tPBM than sham treatment. Both adenosine concentration and cytochrome c oxidase activity were elevated in the frontal cortex targeted by tPBM. These findings suggest that tPBM could be an innovative method for enhancing sleep. Further clinical research is necessary to validate this approach.
- Degree
- Doctor
- Appears in Collections:
- Department of Biomedical Science and Engineering > 4. Theses(Ph.D)
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