Functional and compositional analysis of oral and gut microbiome that accelerates the progression of Alzheimer’s disease

Abstract

Microbiome is closely related to various diseases and lifestyles, including diabetes, obesity, and Alzheimer’s disease. The microbiome, forming communities in diverse locations like the gut, oral cavity, skin, and lungs, produces metabolites for communication within the microbial community and impacting the host. Particularly, the gut-brain axis is related to many neurological disorders, and its modulation could potentially alleviate or treat these conditions. However, the complexity of genetic and environmental factors presents challenges in its analysis. Using shotgun sequencing data enables a more detailed analysis of the microbiome at the species level and allows for functional analysis. Here, I investigated the compositional and functional differences in the gut and oral microbiome of Alzheimer’s disease patients, grouped by progression. Additionally, I analyzed brain RNA-seq data to examine the differences in brain pathways based on the presence of the microbiome, considering the direct invasion of the oral microbiome into the brain.