Application of engineered immunological synaptosomes as a cytokine carrier

Abstract

When T cell interacts with antigen presenting cell (APC) and makes immune synapse, T cell microvilli secretes extracellular vesicle called immunological synaptosome (IS). IS expresses T cell receptor (TCR) and some membrane protein in their surface, it means two possibility of IS. First, IS can activate APC through their TCR. Second, we can engineer T cell and engineered T cell secretes engineered immunological synaptosome (EIS) which expresses specific protein in its surface it can modulate immune response. In this paper, We engineer the T cell to secrete EIS, it can be used as a cytokine carrier to regulate immune response.