Trophoblast apoptosis is increased in women with evidence of T(H)1 immunity

Abstract

Interferon-gamma secretion from peripheral blood mononuclear cells (PBMCs) of women with unexplained recurrent spontaneous abortions was increased by trophoblast Stimulation. Apoptosis was significantly increased in trophoblast cells Cultured with the supernatant of PBMCs from women with evidence of T(H)1 immunity to trophoblast stimulation. (c) 2005 by American Society for Reproductive Medicine.