Peptoid helicity modulation: precise control of peptoid secondary structures via position-specific placement of chiral monomers

Abstract

The degree of peptoid helicity can be effectively modulated by position-specific incorporation of alpha-chiral aromatic monomers. In this study, we report the structural role of each monomer position collected from 30 comprehensive model peptoid oligomers demonstrating a meticulous manner to fine-tune peptoid secondary structures.