Recent Advances in Cell surface Engineering Focused on Cell Therapy

Abstract

Revolutionary progress in stem cell research and the potential of stem cell-based therapeutics promote the translation of cell therapy. However, the therapeutic efficacy of cell therapy is still very low, mainly because of the insufficient homing and survival of the injected cells at the target site. Cell surface engineering is one of the solutions to increase the therapeutic efficacy of cell therapy. Cell surface engineering can modulate the cellular behavior for enhancing targeted delivery, cellular functions, organized structure, and immune evasion by chemical or physical modification of the cell surface. This review summarizes the recent studies in cell surface engineering focused on cell therapy.