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GIST Repository College of Natural Sciences Department of Chemistry 1. Journal Articles

Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents

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Abstract
A series of glutamic acid derivatives was synthesized and evaluated for their antioxidant activity and stability. We found several potent and stable glutamic acid derivatives. Among them, compound 12b exhibited good in vitro activity, chemical stability and cytotoxicity. A prototype compound 12b showed an anti-inflammatory effect in LPS-stimulated RAW 264.7 cell lines and in a zebrafish model. (C) 2017 Elsevier Ltd. All rights reserved.
Author(s)
Pagire, Suvarna H.; Lee, Eunhye; Pagire, Haushabhau S.; Bae, Eun Jung; Ryu, Soo Jung; Lee, Dahye; Kim, Min Hee; Kim, Geum Ran; Hwang, Kyu-Seok; Ahn, Sukyung; Maeng, Jin Hee; Song, Jin Sook; Bae, Myung Ae; Lee, Don Hang; Ahn, Jin Hee
Issued Date
2018-01
Type
Article
DOI
10.1016/j.bmcl.2017.11.012
URI
https://scholar.gist.ac.kr/handle/local/13451
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
Bioorganic and Medicinal Chemistry Letters, v.28, no.3, pp.529 - 532
ISSN
0960-894X
Appears in Collections:
Department of Chemistry > 1. Journal Articles
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