An Optimal Design of an Electromagnetic Actuator for Targeting Magnetic Micro-/Nano-Carriers in a Desired Region

Abstract

Magnetic drug targeting (MDT) by using magnetic nano-particles (MNPs) is a technique used to deliver drug molecules to a desired location. One of the major challenges in MDT is to develop an electromagnetic actuator to focus micro-/nano-particles into a desired deep region. A novel electromagnetic actuation scheme for pushing micro-/nano-particles has been designed to accumulate MNPs in the brain, and an optimal design is studied for the actuation system. The suggested design maximizes the magnetic gradient within a focusing field workspace and allows the accumulation of nano-particles on a specified surface. The configuration and specifications of the optimal design are introduced. Performance of the proposed design was examined through simulations with COMSOL Multiphysics software. The results show that applicability of this scheme is very high in practice because of the simple coil structure and easy guidance scheme.