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Identification of new arylsulfide derivatives as anti-melanogenic agents in a zebrafish model

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Abstract
A series of aryl sulfide derivatives was synthesized and evaluated for their anti-melanogenic activities. Several compounds, including 3e, 3i and 3q exhibited good anti-melanogenic activities. Among the derivatives, compound 3i showed good inhibitory effects against melanin synthesis and showed no toxicity in reconstituted human eye and skin tissues. © 2020 Elsevier Ltd
Author(s)
Ahn S.H.Hwang K.-S.Shin D.-S.Kim S.S.Yang J.Y.Lee B.H.Bae E.J.Choi B.W.Bae M.A.Ahn J.H.
Issued Date
2020-04
Type
Article
DOI
10.1016/j.bmcl.2020.127201
URI
https://scholar.gist.ac.kr/handle/local/12224
Publisher
Elsevier Ltd
Citation
Bioorganic and Medicinal Chemistry Letters, v.30, no.13, pp.127201
ISSN
0960-894X
Appears in Collections:
Department of Chemistry > 1. Journal Articles
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