Design of a rabbit scale 3D magnetic particle imaging system with amplitude modulation

Abstract

Magnetic Particle Imaging (MPI) is a fast and sensitive imaging method that can be used to measure the spatial distribution of superparamagnetic iron oxide (SPIO) nanoparticles. To overcome some limitations of general MPI, the Amplitude Modulation MPI (AM MPI), which uses a low-amplitude excitation field combined with a low-frequency drive field, was suggested. In this paper, we present the design of a rabbit scale 3D AM MPI system with a bore size (9 cm). The AM MPI can reach a drive-field field-of-view (DF-FOV) of 4.00 x 4.00 x 8.00 cm3 and a whole field-of-view (W-FOV) of 6.36 x 6.36 x 8.00 cm3 at 2.2 T/m. © 2020 Le et al.; licensee Infinite Science Publishing GmbH.