Photoredox-Catalyzed alpha-Aminoalkylcarboxylation of Allenes with CO2

Abstract

The photoredox-catalyzed alpha-aminoalkylcarboxylation of aryl allenes with CO2 and N,N-dimethylanilines is reported for the first time (26 examples, up to 96% yield). In the case of electron-deficient allenes, good regioselectivity was observed (up to 94:6), exclusively generating kinetic products over thermodynamic products. This protocol is a novel synthetic method for highly functionalized beta,gamma-unsaturated gamma-aminobutyric esters.