First Human Brain-Scale Magnetic Particle Imaging System with Superconductor

Abstract

Magnetic particle imaging (MPI) is an emerging non-invasive medical imaging method that can determine the concentration and location of superparamagnetic iron oxide (SPIO) nanoparticles. However, the scalability of magnetic particle imaging (MPI) is, currently, the major barrier to its clinical use. For a human bore size MPI, it is important to achieve a high magnetic gradient to obtain high image resolution with a sufficiently large field-of-view (FOV). In this paper, we present a human brain-scale amplitude modulation (AM) MPI system with a bore size of 200 mm. By using superconductor coils, the proposed MPI system can reach a high magnetic field gradient up to 2.5 T/m/µ0 and a 1D-FOV of 97.6 mm (a feasible 3D FOV of 148.8 × 137.6 × 97.6 mm3). These promising results show that the scalability of MPI for human application is not far away. © 2023 Le et al.; and Infinite Science Publishing.