https://scholar.gist.ac.kr/handle/local/7951 2025-12-08T07:47:50Z https://scholar.gist.ac.kr/handle/local/30946 Title: 활성오니로부터 분리된 PCB 분해미생물의 특성과 고정화에 관한 연구 Author(s): 이재석 1995-12-31T15:00:00Z https://scholar.gist.ac.kr/handle/local/20017 Title: 화학기상증착법을 이용한 그래핀의 저온 합성 및 구리/그래핀 배선 특성 Author(s): 김항규; 손명우; 함문호 2018-02-05T15:00:00Z https://scholar.gist.ac.kr/handle/local/17066 Title: 하이아루론산을 기재로 한 하이드로젤-나노입자 복합체와 rhBMP-2를 이용한 골재생 Author(s): Lee, Jong-Ho; Kim, Soung-Min; Park, Jong-Chul; Sung, Mi-Ae; Yu, Sang-Bae; Nam, Jeong-Hun; Chung, Yong-Il; Kim, Jung Ju; Park, Yong Doo; Tae, Gi Yoong Abstract: As an efficient controlled release system of rhBMP-2, a functional nanoparticle-130 KDa5% Hyaluronic Acid (HA) based hydrogel-Nanoparticle(NP) complex was developed and used as a bone transplant. In vivo bone formation was evaluated by soft x-ray, histology, alkaline phosphatase (ALP)/Osteocalcin activity and mineral contents analysis, based on the rat calvarial critical size defect (8 mm in diameter) model. Significantly, effective bone regeneration was achieved with the rhBMP-2 loaded HA based hydrogel-NP complex and the BMP-2 loaded HA based hydrogel as compared to only HA hydrogel group with the period of 4 weeks. These improved results included areas such as radiodensity, the bone specific ALP activity, the osteocalcin immunoreactivity, and the ratio of calcium and phosphate contents with respect to normal bone in the regenerated bone area. Although superiority of bone regenration in the rhBMP-2 loaded HA based hydrogel-NP complex group could not be confirmed statistically, all the evaluation parameters were higher in the rhBMP-2 loaded HA based hydrogel-NP complex group than in the the BMP-2 loaded HA based hydrogel group. These results indicate that the HA based hydrogel with nanoparticle complex can be a promising candidate for a new bone defect replacement matrix, and an enhanced BMP-2 scaffold. 2009-05-31T15:00:00Z https://scholar.gist.ac.kr/handle/local/30936 Title: 하수처리장으로부터 PCB분해 미생물의 분리 및 고정화 Author(s): 이재석 1995-12-31T15:00:00Z